Fast and easy method for predicting the radiosensitivity of cells.

OFFER from Germany, reference: TODE20180709001, valid from 09-07-2018 untill 10-07-2019

Technology
  • Title:
    Fast and easy method for predicting the radiosensitivity of cells.
  • Start date:
    9 juli 2018
  • End date:
    10 juli 2019
  • Summary:
    A German university has developed a method to individualise and thereby optimize radiotherapy for cancer patients. The method detects double-strand breaks induced promptly by radiation to determine the tumour’s radiation sensivity. It requires less sample material and provides results more quickly. Licensees from cancer therapy and research are sought.
  • Description:
    The success of radiotherapy depends on how sensitive the tumour is to radiation. The most important parameters that radiotherapy must consider for optimum results are the radiation sensitivity of the tumour and the normal tissue. Researchers at a German university identified so-called prompt double-strand breaks (prDSBs) as a surrogate predictor of cellular radiation sensitivity. The method enables the determination of radiosensitivity of each tumour, and possibly also of surrounding healthy tissue, and can be used to generate individualized treatment plans.

    The gold standard for determining radiation sensitivity (cell death as function of radiation dose) is the colony formation of single cells. However, the method cannot be implemented for routine use in the clinic because it is too time-consuming and expensive (cell cultivation after irradiation takes 2-3 weeks). The same applies to an alternative approach, which addresses the repair of double-strand breaks (DSBs) as a surrogate predictor of cellular radiation sensitivity. Furthermore, the results are prone to be strongly affected by the physiological status of the cells due to the cultivation, which is necessary for the determination.

    The method invented by the German university solely detects double-strand breaks induced promptly by radiation (prDSBs) and excludes DSBs developing subsequently due to the conversion to breaks of radiation induced heat labile lesions (tlDSBs). Since irradiated cells are analyzed immediately, determination of prDSBs induction is not affected by cell physiology. When using single cell assays, only a few hundred cells are required and results are available within four days. The sample material is taken via fine needle biopsy.

    Licensees are sought from cancer therapy and research. The main potential lies in the clinical use for planning of radiation therapy administered to about half of the patients suffering from cancer. Furthermore, the method could be used in radiation protection and research. The technology is offered for licensing. This could include further development of a test.

Partner Sought
  • Type of Partnership Considered:
    License agreement
  • Technical Specification or Expertise Sought:

    Industrial partners are sought for license agreements to implement the solution. Partners should be active in cancer therapy and research. Applications are in clinical use for planning of radiation therapy administered to about half of the patients suffering from cancer. Furthermore, the method could be used in radiation protection and research. The development of a test could be included in the collaboration.

Organisation
  • Development stage:
    Under development/lab tested
  • IPR Status:
    Patent(s) applied for but not yet granted
  • Market keywords:
    MEDICAL/HEALTH RELATED
    Therapeutic
    Clinical Medicine
    Oncology
  • Technology keywords:
    Medicine, Human Health
    Clinical Research, Trials
    Cytology, Cancerology, Oncology
    Medical Research
  • NACE keywords:
  • Advantages and Innovations:
    This is a new method characterized by reliable correlation of prDSBs with cellular radiation sensitivity
    It offers the following advantages over conventional solutions:
    • Less sample material is required
    • Results are available within a few days as opposed to three weeks presently
    • Easier to handle test for use in the clinic (development planned, also in cooperation with interested parties)
Client
  • Type and Size of Organisation:
    University
  • Already Engaged in Trans-National Cooperation
    Ja
  • Year Established:
    0
  • Turnover:
  • Country of origin:
    Germany
  • Languages spoken
    • English
    • German
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